Status:
COMPLETED
Determinants of Bone and Muscle Quality and Strength in Obesity With and Without Diabetes
Lead Sponsor:
Suzanne Morin
Collaborating Sponsors:
CHU de Quebec-Universite Laval
Conditions:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Eligibility:
All Genders
18-60 years
Brief Summary
Background: Osteoporotic fractures are a major public health issue. They cause substantial disability, loss of autonomy, morbidity and excess mortality. Diabetes is also associated with increased risk...
Eligibility Criteria
Inclusion
- A) Diabetic group
- BMI \>=35 kg/m2
- Clinical diagnosis of type 2 diabetes
- Use of oral hypoglycemic agents or insulin or 2 of the following tests confirming type 2 diabetes: HbA1c \>=6.5%; fasting glucose \>=7.0 mM; 2-h glucose post 75g oral glucose tolerance test (OGTT) \>=11.1 mM)
- B) Non-diabetic group:
- BMI \>=35 kg/m2
- Normoglycemia (HgbA1c \<5.7% and Fasting glucose \<5.6 nM)
Exclusion
- BMI \>60 kg/m2
- Clinical diagnosis of type 1 diabetes
- Disease (e.g. uncontrolled thyroid disease, malabsorptive or overt inflammatory disorder, metabolic bone disease, creatinine clearance \<60 ml/min)
- Medication (e.g. gluccocorticoids, anti-epileptic drugs, osteoporosis therapy and thiazolidinediones) affecting bone metabolism
- Pregnancy
- History of oesophageal, gastric, digestive or bariatric surgery
- Prosthesis that could interfere with interpretation of imaging data
- Chronic severe condition or illness precluding from participation in the project.
Key Trial Info
Start Date :
January 14 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 14 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04093856
Start Date
January 14 2020
End Date
June 14 2021
Last Update
September 1 2021
Active Locations (2)
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1
Research Institute of the McGill University Health Centre
Montreal, Quebec, Canada, H3H 2R9
2
Centre de recherche de l'IUCPQ
Québec, Canada, G1V 4G5