Status:
COMPLETED
Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
Lead Sponsor:
Centre hospitalier de l'Université de Montréal (CHUM)
Collaborating Sponsors:
Unity Health Toronto
Sunnybrook Health Sciences Centre
Conditions:
Acute Kidney Injury
Fluid Overload
Eligibility:
All Genders
18+ years
Brief Summary
Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a ...
Detailed Description
Background: Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ cong...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Admitted to the ICU
- Women with serum creatinine ≥ 100 µmol/L and men with serum creatinine ≥ 130 µmol/L
- Severe acute kidney injury (AKI) defined either: A ≥ 2-fold increase in serum creatinine from a known pre-morbid baseline or during the current hospitalization OR achievement of a serum creatinine ≥ 354 µmol/L with evidence of a minimum increase of 27 µmol/L from pre-morbid baseline or during the current hospitalization OR Urine output \< 6.0 mL/kg over the preceding 12 hours OR initiation of renal replacement therapy (RRT) for severe AKI initiated less than 72 hours before recruitment.
Exclusion
- Lack of commitment to provide RRT as part of limitation of ongoing life support. (Operational definition: Critical care team has deemed the patient not to be eligible for escalation of life support, including the initiation of RRT, or substitute decision makers have declined offer of same.)
- Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate \< 20 mL/min/1.73 m2 in a patient who is not on chronic RRT. (Operational definition: The coordinator will review all documented serum creatinine values within 365 days prior to the date of admission for the current hospitalization. The value closest to the admission date will be considered as the "baseline" and will be used to calculate the corresponding estimated glomerular filtration rate using an online calculator. A value of \< 20 mL/min/1.73 m2 derived from the CKD-EPI equation will be grounds for exclusion.
Key Trial Info
Start Date :
September 4 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2022
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT04095143
Start Date
September 4 2018
End Date
September 1 2022
Last Update
November 14 2022
Active Locations (6)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Kentucky
Lexington, Kentucky, United States, 40506
2
University of Alberta
Edmonton, Alberta, Canada
3
Sunnybrook Health Science Centre
Toronto, Ontario, Canada, M4N 3M5
4
St. Michael's hospital
Toronto, Ontario, Canada, M5B 1W8