Status:
RECRUITING
Registry of Subjects at Risk of Pancreatic Cancer
Lead Sponsor:
Associazione Italiana per lo Studio del Pancreas
Conditions:
Familial Pancreatic Cancer
BRCA1 Mutation
Eligibility:
All Genders
18-80 years
Brief Summary
IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.
Detailed Description
Pancreatic cancer is a devastating disease with a dismal prognosis. One of the ways to improve survival might be early detection. Within years, many predisposing diseases or genetic conditions have b...
Eligibility Criteria
Inclusion
- Inclusion Criteria to enter the registry:
- individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree
- subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
- subjects suffering from FAMMM Syndrome
- subjects suffering from Peutz-Jeghers Syndrome
- subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis
- subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
- Inclusion criteria to join the "radiologic follow-up":
- 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases
- 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer
- 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome
- Exclusion Criteria:
- \- pregnancy
Exclusion
Key Trial Info
Start Date :
August 20 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 20 2045
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT04095195
Start Date
August 20 2019
End Date
September 20 2045
Last Update
January 13 2023
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
Istituto Clinico Humanitas
Rozzano, Milan, Italy
2
Ospedale Pederzoli
Peschiera del Garda, Verona, Italy
3
San Raffele Vita Salute University Hospital
Milan, Italy
4
Chirurgia Generale e del Pancreas
Verona, Italy, 37134