Status:
COMPLETED
Anomalies of Dense Platelet Granules
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Assistance Publique Hopitaux De Marseille
CENTRE DE REFERENCE DES MALADIES HEMORRAGIQUES CONSTITUTIONNELLES
Conditions:
Spontaneous Induced Unexplained Haemorrhagic
Eligibility:
All Genders
2+ years
Brief Summary
The study aims to know the overall prevalence of granular deficits and their breakdown by type (anomaly of number, content or secretion) in a population of patients with hemorrhagic symptomatology aft...
Detailed Description
Patients will be recruited during the exploration visit (v0) or the confirmation/typing visit (v1) according to their follow-up. * Exploration visit (v0): inclusion of patients without prior platelet...
Eligibility Criteria
Inclusion
- Adult or child patient ≥ 2 years
- Having a hemorrhagic score ISTH \> 3 for men, \> 5 for women and \> 2 for children.
- With no abnormal coagulation (defined by normal TP and TCK or activity ≥ 50% of FII, FV, FVII, FX, FVIII, FIX, FXI)
- no deficiency of Willebrand factor (defined by a cofactor activity with Ristoctin (VWF: RCo \< 50%))
- no a known major thrombocytopenia/thrombopathy linked to a deficiency of one of the major platelet receptors
- Information of the patient and/or his legal representative present
Exclusion
- Inability or refusal of compliance with research requirements
- Thrombocytopenia \< 100 G/L
- Treatments interfering with platelet functions within 10 days prior to inclusion
- Malignant hemopathy
Key Trial Info
Start Date :
December 9 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 21 2023
Estimated Enrollment :
166 Patients enrolled
Trial Details
Trial ID
NCT04095715
Start Date
December 9 2019
End Date
February 21 2023
Last Update
October 30 2023
Active Locations (1)
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1
Hôpital Necker Enfants Malades - AP-HP
Paris, France, 75015