Status:
COMPLETED
Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy
Lead Sponsor:
Centre Hospitalier Universitaire de la Guadeloupe
Collaborating Sponsors:
University Hospital Center of Martinique
Groupe Hospitalier Pitie-Salpetriere
Conditions:
Progressive Supranuclear Palsy
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
The main hypothesis is that the gait and postural deficits in the Caribbean form of PSP may be associated with a dysfunction of the cerebral cortex, as they result from sub-cortical involvement in cla...
Detailed Description
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease (6/100 000 inhabitants) characterized by the association of Parkinson's syndrome, a paralysis of the verticality of the gaze an...
Eligibility Criteria
Inclusion
- Patient :
- Patients who met the clinical criteria for PSP and Gd-PSP
- Walking and standing alone without assistance
- Patient or responsible third party who received information about the study and who signed the informed consent
- French
- Patients over 40 years
- Clinically detectable eye movement anomaly
- Witnesses :
- To be affiliated or beneficiary of social security scheme
- French person
- Major subjects, matched for age (± 3 years) and sex, showing no neurological or psychiatric disease or severe progressive disease
- No Indication against MRI
Exclusion
- Patient :
- Patient not affiliated with the social security system
- Cognitive impairment: MMSE ≤ 20; FAB ≤ 12
- psychiatric disorders likely to interfere with exploration; severe postural disorders
- MRI not feasible Witnesses
- Not affiliated or benificiary of social security scheme
- Not a french person
- Somebody showing neurological or psychiatric disease or severe progressive disease
Key Trial Info
Start Date :
September 28 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 12 2018
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04096651
Start Date
September 28 2015
End Date
July 12 2018
Last Update
September 20 2019
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