Status:
UNKNOWN
Effect of DNMT SNPs on DNA Methylation in Primary ITP
Lead Sponsor:
Assiut University
Conditions:
Primary Immune Thrombocytopenia
Eligibility:
All Genders
18-75 years
Brief Summary
* To compare global DNA methylation status between ITP patients and healthy subjects . * To determine the effect of DNMT3A -448 G/A SNP variant A allele and DNMT3B -149C/T SNP variant T-allele on glob...
Detailed Description
Immune thrombocytopenia (ITP), is an immune-mediated acquired disease of adults and children characterized by transient or persistent decrease of the platelet count and, depending upon the degree of t...
Eligibility Criteria
Inclusion
- . Egyptian patients with isolated thrombocytopenia, no organomegaly or lymphoadenopathy, no constitutional symptoms (bone pains, weight loss, and night sweats) and no history of preceding drug intake (quinine, heparin) .
Exclusion
- Conditions/diseases associated with secondary ITP.
Key Trial Info
Start Date :
December 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04100876
Start Date
December 1 2019
End Date
December 1 2021
Last Update
September 24 2019
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