Status:
COMPLETED
Multisystem and Autonomic Complications of NMD on Long-term NIV
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Neuromuscular Diseases
Neurologic Disorder
Eligibility:
All Genders
16+ years
Brief Summary
This exploratory observational study evaluates autonomic function using measures including heart rate variability in adults with childhood-onset neuromuscular and neurological disorders (NMD) who use ...
Detailed Description
Childhood-onset neuromuscular and neurological disorders (NMD) are a diverse group of rare conditions in which muscle function is significantly impaired. Due to progress in NMD management over recent ...
Eligibility Criteria
Inclusion
- Patient group:
- Age ≥16 years
- Confirmed diagnosis of childhood-onset NMD
- Able and willing to provide informed consent
- Requires non-invasive ventilation on an intermittent or continuous basis to manage respiratory failure
- Reference group:
- Age ≥16 years
- No significant co-morbidities
- Not on any regular medications
- Able and willing to provide informed consent
Exclusion
- Inability to travel to hospital site
- Clinical instability or acute deterioration requiring hospitalisation or changes to medication in the previous 4 weeks
- A female of child-bearing potential who is pregnant or intends to become pregnant during study involvement
Key Trial Info
Start Date :
October 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 20 2021
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT04100993
Start Date
October 25 2019
End Date
May 20 2021
Last Update
October 16 2024
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, SW3 6HP