Status:
WITHDRAWN
Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Acute Kidney Injury
Continuous Renal Replacement Therapy
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with longer hospital stays and worse survival. The mortality rate of critically ill patients in the ICU who ...
Detailed Description
This is a single center, prospective, randomized, open label, controlled trial comparing standard-of-care temperature management with blood cooling CRRT. We will recruit approximately 140 patients (70...
Eligibility Criteria
Inclusion
- AKI as defined by 2012 AKI KDIGO guidelines requiring CRRT.
- Patient's core temperature between 35°C and 40°C at the time of recruitment.
- Age 18 years old and older.
Exclusion
- Hypothermia (patient core temperature \<35°C) at the time of recruitment
- Extreme hyperthermia or hyperpyrexia (patient core temperature \>40°C) at the time of recruitment.
- Contraindication to cooling (e.g., hemorrhagic shock or severe coagulopathy)
- Patients undergoing targeted temperature management for cardiac arrest.
- Chronic kidney disease stage 5 as defined by CKD KDIGO guidelines \[19\] requiring renal replacement therapy prior to recruitment.
- Receiving palliative care or immediate plans for withdrawal of life sustaining therapy at the time of recruitment.
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04103307
Start Date
November 1 2020
End Date
December 31 2022
Last Update
March 13 2024
Active Locations (1)
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1
Critical Care Trauma Centre
London, Ontario, Canada, N6A 5W9