Status:
RECRUITING
Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Pelican Cancer Foundation
RM Partners West London Cancer Alliance
Conditions:
Rectal Cancer
Colo-rectal Cancer
Eligibility:
All Genders
16-100 years
Phase:
NA
Brief Summary
When a patient is diagnosed with a rectal (bowel) polyp or cancer, radiology doctors read MRI scans to describe how deeply the cancer invades into the bowel wall (this is the 'stage' of the cancer). I...
Detailed Description
Many patients diagnosed with Early Rectal Cancer (ERC) are currently over-treated. Most patients with confirmed ERC will undergo an MRI, but some are not correctly identified in endoscopy and immediat...
Eligibility Criteria
Inclusion
- Have a rectal tumour or suspected tumour less than or equal to T3b on MRI stage or pT2 or less after excision, or 20mm or more on endoscopy with suspicion of malignancy
- Be aged 16 years or over
Exclusion
- Have metastatic disease at time of initial staging
- Have a biopsy-proven rectal malignancy which is not adenocarcinoma
- Are contraindicated for MRI
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2031
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04103372
Start Date
September 1 2024
End Date
December 31 2031
Last Update
November 4 2024
Active Locations (23)
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1
Royal Berkshire Hospital
Reading, Berkshire, United Kingdom, RG1 5AN
2
Buckinghamshire Healthcare Nhs Trust
Amersham, Buckinghamshire, United Kingdom, AMERSHAM
3
University College London Hospitals Nhs Foundation Trust
London, Greater London, United Kingdom, NW1 2PG
4
King'S College Hospital Nhs Foundation Trust
London, Greater London, United Kingdom, SE5 9RS