Status:
COMPLETED
Optimal Treatment of MRSA Throat Carriers
Lead Sponsor:
Hvidovre University Hospital
Conditions:
MRSA
MRSA Colonization
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The aim of this study is to investigate the optimal way to treat MRSA throat carriers.
Detailed Description
The bacterium Staphylococcus aureus frequently colonizes the human skin and mucous membranes. Longitudinal studies usually divide S. aureus carriers into either persistent or intermittent carriers, bu...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- MRSA carriage in the throat after first topical decolonization treatment (regardless of previous swab results)
- Has completed one standard topical decolonization treatment
Exclusion
- Pregnant or lactating woman
- Sexually active women in the reproductive age that do not use approved contraceptives (appendix 4)
- Cannot read or speak Danish (the written participant information is in Danish)
- Skin infection or other active infections
- Activity in skin diseases such as eczema or psoriasis.
- MRSA isolate resistant to clindamycin (defined by inhibition zone size \< 22 mm using disk diffusion methodology) or resistant to mupirocin
- Allergy to clindamycin, chlorhexidine or mupirocin
- Taking medications that interact with clindamycin according to the medicine information leaflet.
- MRSA active antibiotic treatment within 7 days before inclusion in the study or during study period
- Followed by specialist due to liver disease
- Severe overweight (BMI \> 35) or weight \< 50 kg
- Indwelling percutaneous permanent devices such as intravenous catheters or urinary tract catheters
- Daily contact with pigs or minks (decolonization therapy is generally not offered, according to The National Board of Health)
- Nursing home resident or health care worker (they have a more frequent control swab regime)
- Not being capable of completing another treatment successfully
- MRSA positive household members younger than 2 years (MRSA positive children below 2 years of age and their household members are generally not offered decolonization treatment according to The National Board of Health)
- MRSA positive household members, where it is judged that further decolonization attempts are not indicated
Key Trial Info
Start Date :
May 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 18 2025
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT04104178
Start Date
May 20 2020
End Date
September 18 2025
Last Update
September 24 2025
Active Locations (1)
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1
Hvidovre Hospital
Hvidovre, Denmark