Status:
COMPLETED
Comparison of Innate Immune Responses Induced by Allergy Immunotherapy (AIT) With Different Adjuvants
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Zentrums für Rhinologie und Allergologie Wiesbaden
Conditions:
Allergic Rhinitis
Eligibility:
All Genders
18-50 years
Brief Summary
The primary objective of the pilot study is to compare inflammatory responses in blood sera from patients receiving first allergen immunotherapy (AIT) with aluminium (Alum), microcrystalline tyrosine ...
Detailed Description
This pilot study is an observational study with subsequent use of coded biological material. The blood sera are collected and prepared at the Allergy Units at the University Hospital Zurich (USZ) or C...
Eligibility Criteria
Inclusion
- History of allergy due to IgE sensitisation to any allergen that is treatable by means of AIT, e.g. grass pollen allergens, three pollen allergens, animal dander allergens, dust mite aller-gens, or insect venom allergens.
- Scheduled to receive first AIT with Allergovit oder Polvac at USZ or to receive Pollinex Quattro at AZW.
- Signed written informed consent for subsequent use of coded blood samples including blood leukocytes data and serological data.
Exclusion
- Previous AIT
- Chronic inflammatory diseases (rheumatic diseases, pyelonephritis, osteomyelitis or others)
- Acute infections
- Drug or alcohol abuse within the last 5 years
- Relevant anaemia (as judged by investigator)
- Blood donation within the last 30 days or during the next 7 days
- Pregnancy or breast feeding
- Systemic glucocorticoid or antihistamine therapy within the last 30 days or during the next 7 days.
- Systemic or local immune drug therapy within the last 30 days during the next 7 days.
- For linguistic and/or cognitive reasons unable to understand the study procedures
Key Trial Info
Start Date :
November 5 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2021
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04104828
Start Date
November 5 2019
End Date
October 31 2021
Last Update
March 23 2022
Active Locations (1)
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1
Univeristy Hospital Zurich
Zurich, Switzerland, 8091