Status:
COMPLETED
Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
Chronic Pain Due to Injury
Eligibility:
All Genders
18-66 years
Phase:
PHASE4
Brief Summary
The goal of this study is to test the effects of oxytocin on heart rate variability and pupil diameter, both of which have subtle effects on the activity rate of the autonomic nervous system.
Detailed Description
This protocol focuses on two measures of autonomic control to quantify central actions of oxytocin. First, the study team proposes to examine the influence of oxytocin on heart rate variability with f...
Eligibility Criteria
Inclusion
- Male or female \> 18 and \< 66 years of age,
- Body Mass Index (BMI) \<40
- Generally in good health as determined by the Principal Investigator based on prior medical history
- Normal blood pressure and resting heart rate without medication
Exclusion
- Hypersensitivity, allergy, or significant reaction to any ingredient of Pitocin®
- Any disease, diagnosis, or condition (medical or surgical) that, in the opinion of the Principal Investigator, would place the subject at increased risk
- Women who are pregnant (positive result for serum pregnancy test at screening visit),
- Women who are currently nursing or lactating, women that have been pregnant within 2 years.
- Neuropathy, chronic pain, diabetes mellitus, or taking benzodiazepines or pain medications on a daily basis.
- Previous eye surgery, eye medications, cataracts
Key Trial Info
Start Date :
October 24 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2021
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT04105998
Start Date
October 24 2019
End Date
November 1 2021
Last Update
November 10 2022
Active Locations (1)
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1
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States, 27157