Status:
ACTIVE_NOT_RECRUITING
Study of the Effectiveness of Transcranial Direct Current Stimulation on Obsessive Compulsive Disorder
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The usual management of Obsessive Compulsive Disorders is based on cognitive-behavioural psychotherapy, as well as the use of serotonergic antidepressants. Nevertheless, a significant proportion of pa...
Detailed Description
Obsessive-compulsive disorder (OCD) is a common psychiatric condition (prevalence 2-3%), with a chronic course, and significantly impairs the quality of life and functioning of sufferers quality of li...
Eligibility Criteria
Inclusion
- Presenting an obsessive-compulsive disorder according to the criteria of Diagnostic and Statistical Manual of Mental Disorders 5, evolving for at least two years
- Of significant clinical intensity: Yale-Brown's obsession-compulsion scale ≥ 16/40 continuously over the last 6 months. This criteria of persistent severity over the last 6 months will be explored by an in-depth clinical interview at the inclusion visit (Baseline BL)
- Resistant despite treatment with: 2 serotonergic antidepressants, each received for at least 8 weeks, at the maximum recommended or tolerated dosage AND behavioural and cognitive therapy for at least 6 months
- Drug treatment unchanged for at least 12 weeks
Exclusion
- Patient with psychotic disorder, bipolar mood disorder, substance abuse or dependence (excluding tobacco)
- Patient at risk of suicide (score ≥ 2 on item 10 of the Montgomery-Åsberg depression rating scale)
- Contraindications to the practice of transcranial direct stimulation : history of cerebral pathology, intracranial hypertension, neurosurgery, cephalic metal implant, pacemaker
- Unbalanced epilepsy
- Previous use of transcranial direct stimulation (problem of maintaining the integrity of the blind procedure)
- Pregnancy or breastfeeding in progress, woman in a state of procreation without effective contraception (a urine pregnancy test will be performed)
- Scalp skin pathology
Key Trial Info
Start Date :
September 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 9 2026
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT04106102
Start Date
September 20 2019
End Date
September 9 2026
Last Update
December 2 2025
Active Locations (1)
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1
CHU de Nice
Nice, France, 06003