Status:
COMPLETED
A Study to Evaluate the Effects of Single and Multiple Oral Doses of GLPG3970
Lead Sponsor:
Galapagos NV
Conditions:
Healthy
Psoriasis
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The main purpose of this study is to evaluate the safety and tolerability of GLPG3970 in healthy volunteers after single oral administrations of GLPG3970 (SAD), compared to placebo (part 1 and 1bis) a...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Part 1, 1bis, 2, 3 and 3bis:
- Male between 18-55 years of age (extremes included), on the date of signing the informed consent form (ICF).
- A body mass index (BMI) between 18-30 kg/m2, inclusive.
- Judged to be in good health by the investigator based upon the results of a medical history, physical examination, vital signs, 12-lead electrocardiogram (ECG), and fasting clinical laboratory safety tests available at screening and prior to randomization. Hemoglobin must not be below the lower limit of normal range. Bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) must be no greater than 1.5x upper limit of normal range (ULN). Other clinical laboratory safety test results must be within the reference ranges, or test results that are outside the reference ranges need to be considered not clinically significant in the opinion of the investigator.
- This list only contains the key inclusion criteria for the healthy volunteers part of the study.
- Inclusion criteria for Part 4:
- Male or female between 18-65 years of age (extremes included), on the date of signing the ICF.
- Diagnosed with plaque psoriasis ≥6 months.
- Screening Psoriasis Area and Severity Index (PASI) ≥12 (moderate to severe) and affected body surface area (BSA) ≥10%.
- A body mass index (BMI) between 18-35 kg/m2, inclusive.
- This list only contains the key inclusion criteria for Part 4 of the study.
- Exclusion Criteria for Part 1, 1bis, 2, 3 and 3bis:
- Known hypersensitivity to the Investigational Medicinal Product (IMP) ingredients or history of a significant allergic reaction to IMP ingredients as determined by the investigator.
- Positive serology for hepatitis B virus surface antigen (HBsAg) or hepatitis C virus or history of hepatitis from any cause with the exception of hepatitis A that was resolved at least 3 months prior to first dosing of the IMP.
- History of or a current immunosuppressive condition (e.g. human immunodeficiency virus \[HIV\] infection).
- This list only contains the key exclusion criteria for the healthy volunteers part of the study.
- Exclusion criteria for Part 4:
- Subject has evidence of skin conditions other than psoriasis (e.g., eczema) at the time of screening or baseline visit that would interfere with the evaluation of psoriasis.
- Subject is unable to discontinue systemic therapies and/or topical therapies for the treatment of psoriasis and cannot discontinue phototherapy (UVB or PUVA) from signing of the ICF up to the end of the study.
- This list only contains the key inclusion criteria for Part 4 of the study.
Exclusion
Key Trial Info
Start Date :
September 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 5 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04106297
Start Date
September 10 2019
End Date
March 5 2021
Last Update
September 19 2024
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
SGS Belgium NV - Clinical Pharmacology Unit Antwerp
Antwerp, Belgium, 2060
2
Clinical Republican Hospital Arensia Experimental Medicine
Chisinau, Moldova, MD2025
3
ARENSIA Exploratory Medicine Unit
Kyiv, Ukraine, 01135