Status:
TERMINATED
Neuromuscular Plasticity in Response to Obesity: Effects of Mechanical Overload, Metabolic Disorders and Age
Lead Sponsor:
University Hospital, Clermont-Ferrand
Collaborating Sponsors:
AME2P Laboratory, Clermont Auvergne University
Conditions:
Obesity
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
Obese people suffer from significant functional limitations, which affect their quality of life and limit their physical activity level. Functional abilities are largely determined by neuromuscular pr...
Detailed Description
The limited data available in the literature suggest that insulin resistance, low-grade inflammation and muscle lipid infiltration may negatively impact torque production capacity and promote neuromus...
Eligibility Criteria
Inclusion
- Female or male subject, aged between 20 and 70 years old (inclusive terminals).
- Subject with a BMI greater than 30kg/m².
- Subject with a stable weight for at least 3 months before the start of the study.
- Subject capable and willing to comply with the protocol and willing to give informed consent in writing.
- Subject affiliated to a social security system.
Exclusion
- Subject with a medical or surgical history deemed by the investigator to be incompatible with the study.
- Subject with a medical contraindication to intense activity.
- Subject weighing more than 170kg, which may damage the dynamometer chair.
- Subject with a treatment that, in the investigator's opinion, may interfere with the evaluation of study criteria, period of exclusion from a previous clinical study.
- Subject who has received a total amount of compensation since the beginning of the calendar year, greater than 4500 euros (amount may change depending on the regulation).
- Subject with a linguistic or physiological disability to sign informed consent.
- Subject deprived of liberty by administrative of juridical decision, under guardianship or curatorship.
- Pregnant or breastfeeding women.
Key Trial Info
Start Date :
December 2 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 26 2023
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT04106570
Start Date
December 2 2019
End Date
June 26 2023
Last Update
October 18 2023
Active Locations (1)
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1
Chu Clermont Ferrand
Clermont-Ferrand, France, 63003