Status:
COMPLETED
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Lead Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Conditions:
Septic Shock
Platelet Signal Processing Defect
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets me...
Detailed Description
Background Sepsis, a systemic inflammatory reaction occurring in response to an infection, is a major public health problem and is recognized as the leading cause of death in the intensive care unit ...
Eligibility Criteria
Inclusion
- Informed consent of patients, their relatives or independent physician
- Septic shock defined as a sepsis with vasopressor therapy needed to elevate MAP ≥65 mmHg, and lactate \> 2 mmol/L, despite adequate fluid resuscitation of 30mL/kg of intravenous crystalloid within 6 hours. Inclusion within 48 hours of ICU admission.
- Covid-19 patients with ARDS and PaO2/FiO2 \< 200. Inclusion within 5 days after ICU admission.
Exclusion
- Patients on therapeutic anticoagulation therapy (oral or parenteral) including heparins, fondaparinux, vitamin K antagonist, novel oral anticoagulants, for any reasons DESPITE therapeutic anticoagulation as a treatment for Covid-19 patients.
- Recent (less than 1 month) chemotherapy
- Active inflammatory disease
- Haemophilia and other coagulopathy
- Previous history of thrombocytopenia (\<100 000 platelets/mm3)
- Cirrhosis (Child Plug \> A)
- Recent (less than 48 hours) major surgery
- Exclusion criteria for Covid-19 patients:
- \- bacterial co-infection
Key Trial Info
Start Date :
March 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2024
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04107402
Start Date
March 15 2019
End Date
March 15 2024
Last Update
April 15 2025
Active Locations (1)
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1
Cliniques Universitaires St Luc
Brussels, Belgium, 1200