Status:
UNKNOWN
Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice
Lead Sponsor:
Jiaolin Ning,MD
Conditions:
Jaundice
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
Increased production of vasodilating substances such as NO plays an important role in the development of vasoplegic syndrome caused by obstructive jaundice.Methylene blue plays a role in raising blood...
Detailed Description
The level of circulating hydrogen sulfide (H2S) in patients with obstructive jaundice is significantly increased. As a direct opener of KATP channels in vivo, H2S also has diastolic peripheral vascula...
Eligibility Criteria
Inclusion
- Age: 18\~70 years old;
- ASA grade I\~III;
- Ability to comply with research protocols;
- Patients with obstructive jaundice: patients with total bilirubin greater than 50umol/L;
- Voluntarily participate in the study and sign the informed consent form. -
Exclusion
- ASA IV\~V grade;
- women during lactation and pregnancy;
- Patients with severe heart disease or lung disease before surgery;
- Participating in other trials in the last 2 months;
- Those whose mental state cannot cooperate, who suffer from mental illness, have no self-control, and cannot express clearly;
- Those who refuse to sign the informed consent form. -
Key Trial Info
Start Date :
April 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 21 2021
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT04109859
Start Date
April 1 2019
End Date
January 21 2021
Last Update
October 1 2019
Active Locations (1)
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1
department of anesthesia, Southwest Hospital, Third Military Medical University Affiliation: Southwest Hospital, China
Chongqing, Chongqing Municipality, China, 400038