Status:
UNKNOWN
Mutational Analysis as a Prognostic and Predictive Marker of Cardiovascular (CVD) Disease in Patients With Myelodysplasia
Lead Sponsor:
Sunnybrook Health Sciences Centre
Collaborating Sponsors:
Ontario Molecular Pathology Research Network
Queen's University
Conditions:
MDS
Cardiovascular Diseases
Eligibility:
All Genders
Phase:
NA
Brief Summary
This study evaluates the relationship between myelodysplastic syndromes (MDS) and cardiovascular disease. MDS patients will be evaluated for the presence of mutations and whether they are associated w...
Detailed Description
Myelodysplastic syndromes (MDS) are a type of blood cancer that can cause infection or bleeding because they prevent the formation of blood components and may lead to leukemia and death. MDS can arise...
Eligibility Criteria
Inclusion
- Diagnosis of: myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), Chronic myelomonocytic leukemia leukemia (CMML), or low-blast acute myeloid leukemia (AML, blasts 20-29%) less than 24 months ago
- Alive and registered in the MDS-Canada (MDS-CAN) database
- Known comorbidity history and known history of cardiovascular disease
- Able to provide peripheral blood sample for cytokine analysis
- Able top provide samples for next generation sequencing (NGS) - if diagnosis 0-6 months ago: peripheral blood; if diagnosis 6-24 months ago: diagnostic bone marrow aspirate slides or peripheral blood
Exclusion
- MDS/MPN patients other than CMML due to higher prevalence of Janus Kinase 2 (JAK2) mutation (a known risk factor for CVD)
- Disease progression without available diagnostic bone marrow slides for NGS
Key Trial Info
Start Date :
September 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2021
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04110925
Start Date
September 1 2019
End Date
September 1 2021
Last Update
October 1 2019
Active Locations (1)
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1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5