Status:
COMPLETED
Adrenomedullin Effect on Migraine Without Patients
Lead Sponsor:
Danish Headache Center
Conditions:
Headache, Migraine
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
AM is a naturally occurring peptide in the body and consists of 52 amino acids. AM belongs to the calcitonin gene-related peptide (CGRP) superfamily and has several structural, physiological and pharm...
Detailed Description
AM is a naturally occurring peptide in the body and consists of 52 amino acids. AM belongs to the calcitonin gene-related peptide (CGRP) superfamily and has several structural, physiological and pharm...
Eligibility Criteria
Inclusion
- 18-60 years old
- 50-100 kg
- migraine without aura according International Headache Classification Disorders 3rd edition
Exclusion
- Tension-type headaches more than 5 days a month on average over the past year.
- All other primary headache forms.-
- Headache later than 48 hours before the start of the trial.
- Daily intake of medicines of all kinds except oral contraception.
- Taking any medicine later than 4 times the plasma half-life of that drug (on the day of the trial), except oral contraception.
- Pregnant or breastfeeding women.
- Headache on the day of the trial or later than 48 hours before the administration of the trial drug / placebo
- Migraines within 3 days before the trial date.
- Anamnestic information or clinical signs (on the day of inclusion):
- Hypertension (systolic blood pressure\> 150 mmHg and / or diastolic blood pressure\> 100 mmHg)
- Hypotension (systolic blood pressure \<90 mm Hg and / or diastolic blood pressure \<50 mmHg)
- Cardiovascular diseases of all kinds, including cerebrovascular diseases.
- Anamnestic or clinical signs of mental illness or abuse.
- Patients with glaucoma or prostate hyperplasia
- Anamnestic or clinical signs of illness of any kind that the investigating physician considers relevant for participation in the trial.
Key Trial Info
Start Date :
September 28 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04111484
Start Date
September 28 2019
End Date
January 30 2020
Last Update
March 2 2020
Active Locations (1)
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1
Danish Headache Center
Glostrup Municipality, Denmark, 2600