Status:
ACTIVE_NOT_RECRUITING
Mindfulness-Oriented Recovery Enhancement (MORE) in Heroin Addiction
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
University of Utah
National Center for Complementary and Integrative Health (NCCIH)
Conditions:
Opiate Use Disorder
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
In this study, neuroimaging of reward processing, drug cue reactivity and inhibitory control is used before and immediately after 8 weeks of two types of group therapy in individuals with opioid addic...
Detailed Description
Over the past 15 years, the US has been affected by increasing prescription and illicit opiate/opioid abuse, addiction, and overdose. Research into the enhancement of treatment options for individuals...
Eligibility Criteria
Inclusion
- Ability to understand and give informed consent
- Males and Females 18-64 years of age
- DSM-5 diagnosis of OUD with heroin as the primary drug of choice
- Stabilized on methadone or other form of MAT.
- Inclusion criteria for healthy controls:
- \- The same as inclusion criteria 1-2 above; dependence on nicotine or caffeine is non-exclusionary.
Exclusion
- DSM-5 diagnosis for schizophrenia or developmental disorder (e.g., autism)
- Head trauma with loss of consciousness
- History of neurological disease of central origin including seizures
- Cardiovascular disease including high blood pressure and/or other medical conditions, including metabolic, endocrinological,oncological or autoimmune diseases, and infectious diseases common in iOUD including Hepatitis B and C or HIV/AIDS
- Metal implants or other MR contraindications
- Exclusion criteria for healthy control subjects:
- \- The same, except history of any drug use disorder is prohibitive.
Key Trial Info
Start Date :
June 21 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2031
Estimated Enrollment :
157 Patients enrolled
Trial Details
Trial ID
NCT04112186
Start Date
June 21 2020
End Date
March 31 2031
Last Update
July 3 2025
Active Locations (1)
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1
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029