Status:
COMPLETED
The Effects Diflunisal on the Levels of BMS-986165 in Healthy Participants
Lead Sponsor:
Bristol-Myers Squibb
Conditions:
Healthy Participants
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
BMS-986165 Is broken down by the body through multiple pathways. This study Investigates the effect of blocking one pathway in the drug levels of BMS-986165 in health subjects.
Eligibility Criteria
Inclusion
- For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com.
- Women and men must agree to follow instructions for methods of contraception.
- Participants must be willing and able to complete all study-specific procedures and visits.
- A healthy participant, as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations.
- WOCBP must have a negative serum or urine pregnancy test within 24 hours prior to the start of study treatment.
Exclusion
- Any significant acute or chronic medical condition that presents a potential risk to the participant and/or may compromise the objectives of the study, including a history of active liver disease
- History of biliary disorders, including Gilbert's syndrome or Dubin- Johnson disease, in addition to, current or recent gastrointestinal disease that could impact the absorption of study drug.
- Participants using electronic cigarettes or nicotine-containing products who have stopped smoking less than 6 months prior to dosing on Day 1.
- Consumption of chargrilled meat, quinine, or any nutrient known to modulate CYP enzyme activity within 14 days prior to first administration of study treatment.
- History of any significant drug allergy
- Other inclusion/exclusion criteria apply
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 25 2019
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04113668
Start Date
October 1 2019
End Date
November 25 2019
Last Update
August 5 2020
Active Locations (1)
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1
PRA Health Sciences - Lenexa
Lenexa, Kansas, United States, 66219