Status:
COMPLETED
Concurrent Assessment of Skeletal Muscle Mass and Synthesis/Breakdown in Old Age
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
Abbeyfield
Conditions:
Sarcopenia
Muscle Atrophy
Eligibility:
All Genders
65-85 years
Brief Summary
This study involves minimally-invasive techniques to measure muscle mass, muscle protein breakdown and synthesis simultaneously in older age.
Detailed Description
Most people will have noticed that with age people become frail. This is principally due to wasting of skeletal muscle known as "sarcopenia". Crucially, sarcopenia is more than just a symptom of weakn...
Eligibility Criteria
Inclusion
- \- Healthy volunteers of normal body mass index (BMI \<35 kg/m2), aged 65-85 years
Exclusion
- A BMI \> 35 kg/m2
- Active cardiovascular disease:
- o angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event
- Cerebrovascular disease:
- o previous stroke, aneurysm (large vessel or intracranial), epilepsy
- Respiratory disease including:
- o pulmonary hypertension, COPD
- Metabolic disease:
- o hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, type 1 or 2 diabetes
- Active inflammatory bowel or renal disease
- Malignancy
- Recent steroid treatment (within 6 months) or hormone replacement therapy
- Clotting dysfunction
Key Trial Info
Start Date :
June 7 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2020
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT04114383
Start Date
June 7 2016
End Date
February 1 2020
Last Update
March 25 2020
Active Locations (1)
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1
Royal Derby Hospital Medical School
Derby, Derbyshire, United Kingdom, DE22 3DT