Status:
UNKNOWN
Poor Response to Monoclonal Therapy in Asthma
Lead Sponsor:
University of Nottingham
Conditions:
Asthma
Eligibility:
All Genders
18-80 years
Brief Summary
Asthma affects 8% of the entire population. 4-5% of asthma sufferers have severe asthma, characterised by recurrent exacerbations (worsening of symptoms leading to the person having a bout of corticos...
Eligibility Criteria
Inclusion
- Inclusion criteria: case participants:
- Aged 18 - 80 years old
- Able to give informed consent
- All patients identified as being suitable for anti-IL5 therapy by the asthma MDT will be considered for study enrolment.
- This assessment by the MDT for participants to be eligible includes:
- A measure of compliance with current asthma medication,
- Confirmation of asthma diagnosis
- Suitability for anti-IL5 therapy based on blood eosinophil counts,
- Asthma exacerbation rates
- Prednisolone dose.
- Confirmation of treatment requires at least two asthma specialists to agree that this is the correct course of action
- Patients must first demonstrate over 75% compliance with inhaled and/or oral corticosteroid therapy
- The asthma MDT and difficult asthma clinic normally assess patients between 18-80 years so only patients in this age range will be approached.
- All patients will be able to give informed consent for study participation.
- Exclusion criteria: case participants:
- • Pregnancy
- Inclusion criteria: control participants:
- Aged between 18-80 years old.
- Able to give informed consent
- Exclusion criteria: control participants:
- Pregnancy
- Underlying respiratory conditions
Exclusion
Key Trial Info
Start Date :
December 31 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04114396
Start Date
December 31 2018
End Date
July 31 2021
Last Update
November 3 2020
Active Locations (1)
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1
Nottingham Respiratory BRU
Nottingham, United Kingdom, NG51PB