Status:
TERMINATED
Shake It Up: Lipidomics of Lipoproteins and Diet
Lead Sponsor:
USDA Grand Forks Human Nutrition Research Center
Conditions:
Overweight
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
The purpose of this research is to understand how dietary fat is related to cardiovascular disease (CVD). This study tests the effect of different dietary fats on the level of fat in the blood and the...
Detailed Description
The overall objective of this work is to discover how the lipidomic composition of postprandial lipoproteins responds to dietary fats of differing fatty acid composition by comparing meals rich in sat...
Eligibility Criteria
Inclusion
- Normal to overweight (BMI 18.0-29.9 kg/m\^2
- Willing to comply with the demands of the experimental protocol
Exclusion
- Inability to provide consent
- Have fasting blood glucose \<60 mg/dL or \>126 mg/dL
- Have fasting blood cholesterol \>300 mg/dL
- Have fasting blood triglyceride \<100 mg/dL or \>300 mg/dL
- Have uncontrolled hypertension (blood pressure \>140/90 mm Hg)
- Take prescription medications for blood sugar or lipid management or anti-inflammatory steroids (e.g. cortisone)
- Over the counter use of supplements (fish oil, flax, plant sterol or sterol esters) and unwilling to discontinue use for 6 weeks prior to study initiation
- Have a history of an eating disorder, unusual dietary pattern (extreme nutrient or food group restriction; erratic meals due to shift work, etc.)
- Have established cardiovascular, pulmonary, and/or a metabolic disease such as diabetes
- Have cancer
- Use tobacco products or nicotine in any form including snuff, pills, and patches, or e-cigarettes/vaping in the past 6 weeks
- Have alcohol, anabolic steroids, or other substance abuse issues
- Consume more than 3 alcoholic drinks/week
- Are lactose intolerant or have an allergy to dairy foods
Key Trial Info
Start Date :
November 12 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 20 2022
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT04120220
Start Date
November 12 2019
End Date
May 20 2022
Last Update
August 4 2022
Active Locations (1)
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1
USDA Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States, 58203