Status:
COMPLETED
Perioperative Care of HVPG Measurement (CHESS1904): An International Multicenter Survey
Lead Sponsor:
Hepatopancreatobiliary Surgery Institute of Gansu Province
Collaborating Sponsors:
LanZhou University
Shandong Provincial Hospital
Conditions:
Portal Hypertension
Cirrhosis, Liver
Eligibility:
All Genders
18-75 years
Brief Summary
Hepatic venous pressure gradient (HVPG) is an invasive test and requires technical skills of the operator and specialized instruments. HVPG measurement and anesthesia can cause stress responses in the...
Detailed Description
Portal hypertension is an important factor affecting the clinical outcomes of cirrhosis patients, and its severity determines the occurrence of development of cirrhosis complications, such as rupture ...
Eligibility Criteria
Inclusion
- Eligible participants must meet the following criteria:
- aged between 18-75 years, no restriction on gender;
- clinically and/or pathologically diagnosed sinusoidal cirrhosis;
- with written informed consent
- scheduled to undergo HVPG measurement according to the following indications: 1) assessment of the efficacy of primary and secondary prophylactic drugs for gastroesophageal variceal bleeding; 2) predicting the risk of gastroesophageal variceal bleeding and guiding the selection of the treatment regimens; 3) predicting of risk, progression, and clinical outcomes of decompensation events in cirrhosis; 4) evaluation of the efficacy of new drugs; 5) evaluation of the accuracy of new non-invasive techniques; diagnosis and differential diagnosis of types of portal hypertension.
Exclusion
- Those cases that meet any of the following criteria should be excluded:
- contradictions for HVPG measurement;
- pregnant or lactating woman;
- severe coagulopathy (international normalized ratio\>5);
- severe heart, lung, or kidney disease.
Key Trial Info
Start Date :
October 16 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04121520
Start Date
October 16 2019
End Date
August 1 2022
Last Update
April 25 2023
Active Locations (10)
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1
Universidade Federal de Pernambuco
Recife, Brazil
2
The First Hospital of Lanzhou University
Lanzhou, Gansu, China
3
Xingtai People's Hospital
Xingtai, Hebei, China
4
Shandong Provincial Hospital affiliated to Shandong University
Jinan, Shandong, China