Status:
COMPLETED
Vitamin D Supplementation in Knee Osteoarthritis
Lead Sponsor:
Intermountain Health Care, Inc.
Collaborating Sponsors:
USANA Health Sciences
Conditions:
Osteoarthritis, Knee
Vitamin D Supplementation
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Muscular (i.e., quadriceps) weakness is a major risk factor for predisposing the knee to osteoarthritis, impairing physical function, and increasing patient-reported pain. Muscular weakness is a conse...
Detailed Description
Knee osteoarthritis (OA) is a degenerative joint condition and a leading contributor to the global burden of disease. Estimates indicate that approximately 14 million people in the United States have ...
Eligibility Criteria
Inclusion
- Unilateral knee pain, weakness, and impaired physical activity
- Older than 18 years of age but younger than 60 years of age
- Reportedly physically active (minimum of 30 minutes of continuous exercise or physical exertion 3 times per week during the previous year)
Exclusion
- Bilateral symptoms of hip, knee or ankle osteoarthritis
- Recent (within 2 years) surgery on the symptomatic or non-symptomatic limb
- History of metabolic bone disease
- History of any skeletal muscle pathologies
- History of cardiac or peripheral cardiovascular system abnormalities
- History of clotting disorders
- History of coronary artery disease, peripheral vascular disease, or stroke
- History of cancer
- Use of warfarin or other anti-coagulants prior to study enrollment
- Use of cholesterol lowering medication
- History of high cholesterol or triglycerides
- History of high blood pressure
- Diagnosed with diabetes mellitus
- Impaired liver function
- Impaired kidney function
- Pregnant
- Daily dietary supplement or vitamin use during the previous year
- Use of corticosteroid medication
- Use of orlistat, phenobarbital, phenytoin, or thiazide
- Morbidly obese (body mass index \> 40 kg/m2)
Key Trial Info
Start Date :
July 28 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 8 2013
Estimated Enrollment :
73 Patients enrolled
Trial Details
Trial ID
NCT04121533
Start Date
July 28 2011
End Date
January 8 2013
Last Update
October 10 2019
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