Status:
TERMINATED
The Role of Unsteady Wall Shears Stress Stimuli on Human Umbilical Vein Endothelial Cells Harvested From Umbilical Cords
Lead Sponsor:
University Hospital of Limerick
Collaborating Sponsors:
University of Limerick
Conditions:
Vascular Diseases
Eligibility:
FEMALE
18-40 years
Brief Summary
The aim of this study is to obtain and test endothelial cells (EC's) from umbilical cords to examine specific properties of these cells which make up the inner lining of blood vessels.
Detailed Description
Mechanical testing will be performed on the Ec's to see how the cells reacts and ultimately how the blood vessel is affected. A central role in the mechanism that defines the nature of vessel remodel...
Eligibility Criteria
Inclusion
- Patients who are attending the Maternity Services who are pregnant and due for routine delivery.
- Aged 18- 40 years.
- Are willing and capable to voluntarily sign a statement of informed consent to take part in this investigation.
- Patients due to give birth to twins will be included in this study. Women having both "normal" delivery and caesarean section delivery will be included in this study.
Exclusion
- Patients unable to provide informed consent.
- Patients who are under the age of 18 and over the age of 40 years.
- Patients who are deemed unsuitable due to any circumstances as deemed appropriate by the Consultant.
- Patients with a Blood Borne Virus (HIV Type 1, HIV Type 2, Hepatitis B, Hepatitis C) will be excluded from the study.
- Patients with diabetes that is not gestational in nature will be excluded from this study.
- Patients due to deliver triplets or more will be excluded from this study.
- Patients who deliver their baby before 37 weeks gestation will not have umbilical cord tissue retained for study purposes.
Key Trial Info
Start Date :
November 20 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 22 2024
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT04122794
Start Date
November 20 2019
End Date
March 22 2024
Last Update
April 12 2024
Active Locations (1)
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1
University Hospital Limerick
Limerick, Ireland