Status:
COMPLETED
Genetic Variants Replication Study Associated With Dependence on Sulfonylurea in Participants With Type 2 Diabetes
Lead Sponsor:
Seoul National University Hospital
Conditions:
Diabetes Mellitus
Eligibility:
All Genders
19+ years
Phase:
PHASE4
Brief Summary
This study was designed to reproduce candidate single nucleotide variants found by whole exome sequencing in some type 2 diabetic patients dependent on sulfonylurea in a separate patient group. The va...
Detailed Description
Sulfonylurea, one of the oral hypoglycemic agents, is the oldest and most widely used drug. The use of sulfonylurea was overwhelming compared to metformin especially in East Asia, where insulin secret...
Eligibility Criteria
Inclusion
- Among patients with type 2 diabetes who visited Seoul National University Hospital endocrinology outpatient clinic, all of criteria (1)-(4) are satisfied
- Adults over 19 years
- More than 10 years of diabetes
- Low dose sulfonylurea use: Equivalent capacity 2 mg or less of glimepiride
- Less than 7.5% of glycated hemoglobin for more than 6 months
- estimated glomerular filtration rate \> 50 mL/min/1.73㎡
Exclusion
- Type 1 diabetics
- Insulin user
- Patients diagnosed with cardiovascular disease, cancer, and other critical illness within 6 months before the study
- Patients with severe hypertension
- Patients with treatment or diseases that may have a significant effect on blood glucose levels, such as glucocorticoids and thyrotoxicosis
Key Trial Info
Start Date :
September 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2020
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT04123587
Start Date
September 10 2019
End Date
November 30 2020
Last Update
December 16 2020
Active Locations (1)
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1
Seoul National University Hospital
Seoul, South Korea, 110-144