Status:
COMPLETED
Efficacy of Extract of Trigonella Foenum-graceum as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women
Lead Sponsor:
Indonesia University
Conditions:
Skin Aging
Eligibility:
FEMALE
Phase:
PHASE1
PHASE2
Brief Summary
Skin is subjected to intrinsic aging and extrinsic aging. Intrinsic aging is influenced by genetic and hormonal factors. Estrogen has significant role in modulating skin physiology. In post menopausal...
Detailed Description
In this double-blinded unmatched randomized controlled trial, the investigators intend to study the efficacy of Trigonella foenum-graceum extract as topical phytoestrogen in skin aging treatment of po...
Eligibility Criteria
Inclusion
- Women with minimum 2 years post menopausal and maximum 8 years post menopausal
- Have skin aging problems that manifested as wrinkles on forehead, crow's feet, and nasolabial fold region
- Estradiol level \< 30 pg/mL
- Willing to terminate the routine use of facial cream or treatment during the study duration and at least for 30 days before the study commence
- Willing to follow the study protocol and sign the informed consent
Exclusion
- Dermatitis in the region of face
- Using oral/topical hormonal supplement in the last 12 months
- Using products containing retinoic acid or it's derivatives in the last 30 days
- Underwent radiotherapy, facelift, dermabrasion, botox, or facial filler procedures in the last 5 years
- Breast lump or other breast abnormality
- History of cancer or malignancy
- Vein thrombosis
- History of hormonal contraception allergy
- History of ovariectomy
Key Trial Info
Start Date :
August 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 10 2019
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT04123743
Start Date
August 10 2019
End Date
November 10 2019
Last Update
July 29 2020
Active Locations (1)
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1
Faculty of Medicine, Universitas Indonesia
Jakarta Pusat, DKI Jakarta, Indonesia, 10430