Status:
ACTIVE_NOT_RECRUITING
Home-based Exercise in Renal Transplant Recipients
Lead Sponsor:
University of Leicester
Conditions:
Kidney Transplant; Complications
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Although patients who have received a kidney transplant have better health than patients on dialysis, heart problems are still the commonest cause of death for kidney transplant recipients. This is be...
Detailed Description
Kidney transplantation confers a significant survival advantage over remaining on dialysis, but CVD remains the leading cause of death for RTRs and of graft loss. Acute myocardial infarction accounts ...
Eligibility Criteria
Inclusion
- Age great than 18 years old
- Prevalent RTR longer than 1year
- Able and willing to give informed consent
- Increased cardiometabolic risk, with at least one of:
- Diabetes mellitus Dyslipidaemia Hypertension History of ischaemic heart disease or cerebrovascular disease Obesity (BMI above 30)
Exclusion
- Unable to undertake exercise due to physical or psychological barriers
- Unable to undergo CMR scanning (incompatible implants, claustrophobia, allergy to agents)
- Contraindication to exercise training (American College of Sports Medicine guidelines)
- Female participants who are pregnant, lactating, or planning pregnancy during the course of the study.
- Scheduled elective surgery or other procedures requiring general anaesthesia during the study.
- Any other significant disease or disorder (i.e. significant co-morbidity including unstable hypertension, potentially lethal arrhythmia, myocardial infarction within 6 months, unstable angina, active liver disease, uncontrolled diabetes mellitus (HbA1c greater than or equal to 9%), advanced cerebral or peripheral vascular disease) which, in the opinion of the patient's own clinician the Principle Investigator may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.
- Inability to give informed consent or comply with testing and training protocol for any reason.
Key Trial Info
Start Date :
January 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04123951
Start Date
January 30 2020
End Date
June 30 2027
Last Update
December 9 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Leicester NHS Trust
Leicester, Leicestershire, United Kingdom, LE5 4PW