Status:
COMPLETED
Safety and Efficacy Study of Radioembolization in Combination With Durvalumab in Locally Advanced and Unresectable HCC
Lead Sponsor:
Seoul National University Hospital
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
19+ years
Phase:
PHASE1
PHASE2
Brief Summary
Safety and Efficacy Study of Radioembolization with Yttrium-90 Microspheres in Combination with Durvalumab in Locally Advanced Hepatocellular Carcinoma
Detailed Description
This is a single arm, open-label study to evaluate safety and efficacy of Radioembolization with Yttrium-90 Microspheres in Combination with Durvalumab in Locally Advanced and Unresectable Hepatocellu...
Eligibility Criteria
Inclusion
- Diagnosed with unequivocal HCC confirmed histologically or diagnosed radiologically
- Locally advanced HCC
- Must have at least 1 untreated measurable disease
- Child-Pugh score ≤7 points
- Adequate normal organ and marrow function.
Exclusion
- Eligible for potentially curative treatment (surgical resection, radio-frequency ablation or immediate liver transplantation)
- Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti- Cytotoxic T-lymphocyte-associated antigen-4 (anti-CTLA-4) antibody
- Any other concurrent malignancy, except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, papillary thyroid cancer, early gastric cancer, or other cancer for which the patient has been disease-free for at least five years.
- Evidence of extrahepatic metastasi(e)s, except for regional lymph node(s) involvement
- History of leptomeningeal carcinomatosis , History of active primary immunodeficiency
- Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab.
- Exclusion Criteria Specific to Radioembolization:
- •The screening angiogram and technetium-99m macroaggregated albumin (99mTc-MAA) scan are used to determine lobar liver volume from CT or MR images, to identify vascular shunting to the GI tract requiring use of angiographic occlusion techniques and to determine the lung shunt fraction.
- Patients who are ineligible to radioembolization meeting the following criteria will not be included in the study. Additional patients will be screened to replace those patients.
- Deposition of yttrium-90 microspheres to the GI tract that cannot be corrected by placement of the catheter distal to collateral vessels or the application of standard angiographic techniques, such as coil embolization to prevent deposition of yttrium-90 microspheres in the GI tract.
- Exposure of radiation to the lungs exceeds 30 Gray (Gy) for a single infusion or 50 Gy cumulative for all infusions of yttrium-90 microspheres.
Key Trial Info
Start Date :
June 12 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 28 2022
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04124991
Start Date
June 12 2020
End Date
July 28 2022
Last Update
March 16 2023
Active Locations (1)
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1
Seoul National University Hospital
Seoul, South Korea, 03080