Status:
COMPLETED
Role of Mitochondrial Dysfunction in the Occurrence of Acute Kidney Injury (AKI) in Postoperative Cardiac Surgery
Lead Sponsor:
University Hospital Center of Martinique
Conditions:
Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery Requiring Extracorporeal Circulation
Eligibility:
All Genders
18-85 years
Brief Summary
Cardiac Surgery and Acute Kidney Failure (AKI) post Surgery: AKI is a frequent complication in the immediate aftermath of cardiac surgery with an incidence varying from 5 to 40%. KDIGO criteria (Kidn...
Detailed Description
Primary objective of the research: Describe the association between preoperatives mitochondrial dysfunction markers and the occurrence of AKI in postoperative cardiac surgery with ECC. Secondary obj...
Eligibility Criteria
Inclusion
- Be between 18 and 85 years old,
- Patients undergoing coronary artery bypass graft requiring circulation extracorporeal,
- Have been informed of the research,
- Having defended its decision of non-opposition to the research on samples taken during the treatment and on the data medical file,
- Patients affiliated to a social security scheme.
Exclusion
- Pregnant or nursing woman,
- Diabetic type 1,
- Emergency cardiac surgery,
- Valvular replacement surgery,
- Clinical heart failure or ejection fraction of the ventricle left EFVG \<50%,
- Valvular pathology,
- Left atrial dilation\> 40 mm,
- Systolic pulmonary arterial pressure\> 40 mmHg,
- BNP (Brain natriuretic peptide) level\> 100 ng / L,
- Atrial fibrillation or flutter,
- Right coronary stenosis\> 50%,
- Chronic renal failure defined by a filtration rate Glomerular GFR (GFR) less than 60 ml / min / 1.73 m2 estimated from creatinine by the equation CKD-EPI (Chronic Kidney Disease - Epidemiology Collaboration).
Key Trial Info
Start Date :
October 2 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 2 2022
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04125069
Start Date
October 2 2019
End Date
January 2 2022
Last Update
February 24 2022
Active Locations (1)
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1
CHU de Martinique
Fort-de-France, France, 97200