Status:

UNKNOWN

Metagenomic Next-Generation Sequencing for Diagnosis of Ascites Infection in End-stage Liver Diseases

Lead Sponsor:

Nanfang Hospital, Southern Medical University

Collaborating Sponsors:

Meng Chao Hepatobiliary Hospital of Fujian Medical University

The First Hospital of Jilin University

Conditions:

Ascites Infection

Eligibility:

All Genders

18+ years

Phase:

NA

Brief Summary

Ascites is the most common complication of cirrhosis, and its development is associated with substantially increased mortality. Ascites infection including spontaneous bacterial peritonitis (SBP), bac...

Detailed Description

The study is divided into 2 parts: Firstly, the study will test 3 types of sample by means of mNGS, including ascites fluid, peritoneal dialysis fluid and postoperative drainage fluid and evaluate th...

Eligibility Criteria

Inclusion

  • Hospitalization cirrhotic patients;
  • Age \>18 years old;
  • Paitents with ascites at hospital admission.

Exclusion

  • Pregnant women;
  • Hepatic tumor or extrahepatic related cancer;
  • Identified secondary peritonitis;
  • Ascites not related to portal hypertension;
  • Not provide written consent.

Key Trial Info

Start Date :

August 12 2019

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

February 28 2021

Estimated Enrollment :

300 Patients enrolled

Trial Details

Trial ID

NCT04125654

Start Date

August 12 2019

End Date

February 28 2021

Last Update

August 14 2020

Active Locations (1)

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1

Nanfang Hospital

Guangzhou, Guangdong, China, 510515