Status:
UNKNOWN
Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease
Lead Sponsor:
Fakultas Kedokteran Universitas Indonesia
Conditions:
Autoimmune Uveitis
Behçet Disease
Eligibility:
All Genders
18+ years
Brief Summary
This study aimed to discover the composition on the microbiome in several sites of the human body; and to find out the difference in microbiome composition on ocular fluid, blood, and feces before and...
Detailed Description
Gut microbiome has been widely studied around the globe, and it is convinced that the gut microbiome plays an essential role in many human diseases. In a published review showed the presence of microb...
Eligibility Criteria
Inclusion
- New patient registered at Cipto Mangunkusumo Hospital since November 2019
- Patient diagnosed with non-infectious uveitis (with Behcet, VKH history)
- Patient idiopathic uveitis (proven to have negative result by available etiological uveitis work-ups)
- Minimum age: 18 years old
- Experience active inflammation in the past 180 days and or during patient registration following Standard Uveitis Nomenclature (SUN) guidelines, in at least:
- equal and or more than 2+ anterior chamber cells
- equal and or more than 2+ vitreous haze and/or
- active retinal/choroidal lesions
Exclusion
- patients had taken probiotics supplement or antibiotics 3 months before sample collection
- or who experience prolonged diarrhea or constipation
- or undergone gastrointestinal surgery
- having any form of malignancy
- having a systemic disease such as hypertension, obesity, inflammatory bowel disease, or diabetes.
- Disagree to sign informed consent
- Uveitis is proven to be an infectious origin
- Pregnant patient
- Loss to follow up patient
- Healthy volunteers are recruited for this study after giving consent with the following inclusion criteria:
- age: 18-50 years old (Man/Woman)
- having no health complaints or symptoms
- not in any long term medications
- having no history of allergy
- willing to cooperate in the study
- state of complete physical, mental and social well being
Key Trial Info
Start Date :
November 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 30 2020
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04126850
Start Date
November 1 2019
End Date
July 30 2020
Last Update
October 17 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
RSUPN dr. Cipto Mangunkusumo (Cipto Mangunkusumo Hospital)
Jakarta Pusat, Jakarta Special Capital Region, Indonesia, 10320