Status:
UNKNOWN
Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects
Lead Sponsor:
Meenakshi Ammal Dental College and Hospital
Conditions:
Periodontal Diseases
Coronary Artery Disease
Eligibility:
MALE
30-65 years
Brief Summary
Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease. Th...
Detailed Description
The study is done in order to assess the demographic variables such as age, height, weight and socio-economic status, BMI, personal habits, waist-hip ratio, lipid profile, use of medications, and fami...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients willing to participate in the study
- Patients within the age group of 30-65 years ( male )
- Patients should have ≥ 20 remaining natural teeth
- No history of long term antibiotic use in the past 6 months
- For group I generalized chronic periodontitis patients with coronary heart disease
- For group II generalized chronic periodontitis patients without coronary heart disease
- Exclusion criteria:
- Patients with systemic conditions such as type I, and type II diabetes mellitus, respiratory diseases, renal disease, liver disease, rheumatoid arthritis, allergy, advanced malignancies and hiv infection will be excluded from the present investigation.
- Patients on drugs such as corticosteroids, antibiotics within 3 months of investigation will be excluded.
- Current smokers, individuals who quit smoking less than 6 months ago.
- Patients who had undergone periodontal therapy within the previous 6 months
Exclusion
Key Trial Info
Start Date :
October 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT04127487
Start Date
October 1 2019
End Date
December 1 2020
Last Update
December 3 2019
Active Locations (1)
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1
Jaideep Mahendra
Chennai, Tamil Nadu, India, 600095