Status:
COMPLETED
Sex Differences in Vascular Responses to Exercise
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Aging
Eligibility:
All Genders
60-79 years
Phase:
NA
Brief Summary
A key early event in cardiovascular disease development is endothelial dysfunction, characterized by impaired flow-mediated dilation. Regular aerobic exercise ameliorates endothelial dysfunction in he...
Eligibility Criteria
Inclusion
- adults able to give consent
- men and women
- women must be postmenopausal (either natural or surgical)
- 60 to 79 years of age
Exclusion
- any relevant cardiovascular diseases (e.g., history of coronary artery bypass surgery or angioplasty, or heart failure, myocardial infarction, angina pectoris, peripheral arterial disease)
- myocardial ischemia during maximal graded exercise test
- major chronic clinical disease (e.g., diabetes, renal or hepatic disease or infection with hepatitis B, C, or HIV)
- seizures, or other relevant on-going or recurrent illness
- recent (within 3 months) or recurrent hospitalizations
- systolic blood pressure \< 100 mmHg
- body mass index \> 35 kg/m\^2
- \>5% weight change in past 3 months or unwilling to remain weight stable during study participation
- use of tobacco products including smoking traditional or e-cigarettes
- use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone)
- regular aerobic exercise training (≥30 min/session and ≥ 3 days/week)
Key Trial Info
Start Date :
November 22 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04128215
Start Date
November 22 2019
End Date
May 31 2023
Last Update
November 14 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Integrative Cardiovasculal Physiology Laboratory, University of Florida
Gainesville, Florida, United States, 32611