Status:
COMPLETED
Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients
Lead Sponsor:
Samir Saba
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18-75 years
Brief Summary
This is a prospective, observational study that will examine endothelial dysfunction in atrial fibrillation before and after treatment with anti-arrhythmic agents and the extent to which baseline endo...
Detailed Description
This will be a prospective, observational study and roughly 60 patients will be recruited based on strict inclusion/exclusion criteria. Goal population includes adult patients with a diagnosis of paro...
Eligibility Criteria
Inclusion
- Adult patients (18-75 years of age) with paroxysmal or persistent atrial fibrillation
- Patients who recovered from prior tachycardia induced cardiomyopathy will be allowed to enroll in the study.
Exclusion
- Exclusion criteria will include:
- age \>75 years
- history of cardiomyopathy
- history of severe cardiac valvular disease
- history of coronary artery disease
- pulmonary artery hypertension
- congenital heart disease
- history of stroke
- chronic hypoxia
- recent worsening or flare up of obstructive or restrictive lung disease
- liver cirrhosis
- stage three or worse chronic kidney disease
- any major trauma or surgery within the preceding 3 months
- uncontrolled hyperthyroidism
- uncontrolled hypertension
- uncontrolled diabetes mellitus
- active malignancy
- poorly controlled connective tissue disease
- any acute or chronic inflammatory or infectious disease
- Patients who are already on class I or class III antiarrhythmic agents will be excluded from the study
- Patients on non-dihydropyridine calcium channel blockers and beta blockers will not be excluded from the study, as these agents are not considered anti-arrhythmics and are not hypothesized to affect endothelial function.
Key Trial Info
Start Date :
May 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04128878
Start Date
May 1 2019
End Date
December 31 2020
Last Update
January 14 2021
Active Locations (1)
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1
University of Pittsburgh Medical Center - Presbyterian University Hospital
Pittsburgh, Pennsylvania, United States, 15201