Status:
COMPLETED
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Lead Sponsor:
Medical University of South Carolina
Conditions:
Stroke
Stroke Sequelae
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity...
Detailed Description
The investigators aim to determine the effects of taVNS on motor cortex excitability. The hypothesis is that taVNS alone (sham rTMS + active taVNS) will induce increases in motor cortex excitability (...
Eligibility Criteria
Inclusion
- Age 18-80
- endorsing good health
Exclusion
- no TMS-induced motor cortex excitability changes in response to 20Hz motor cortex rTMS
- active psychiatric or neurological disorders
- history of CNS disease, concussion, overnight hospitalization, or other neurologic sequelae, tumors, seizures, frequent or severe headaches
- metal implanted above the neck
- currently taking seizure reducing medications
- currently taking psychotropic medications
- any psychotropic medication taken within 5 half-lives of procedure time
- abuse or dependence of drugs (excluding nicotine and caffeine)
- currently taking medications that lower the seizure threshold
- taking any of the stimulants, thyroid medication, or steroids
- implanted devices/ferrous metal of any kind
- history of seizure or seizure disorder
- inability to determine motor threshold.
- Pregnant females and children under the age of 18 will be excluded for safety reasons
- No vulnerable populations or special classes of subjects will be considered for participation.
Key Trial Info
Start Date :
March 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 6 2024
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04130646
Start Date
March 15 2020
End Date
December 6 2024
Last Update
April 20 2025
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425