Status:
UNKNOWN
Aerosol Particle Size and Breathing Pattern During Inhaled Furosemide
Lead Sponsor:
Oxford Brookes University
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The study hypothesises that the variability in relief of air hunger with inhaled furosemide that is reported in previous studies can be explained by the breathing pattern adopted during the inhalation...
Detailed Description
Recent studies suggest that inhaling furosemide as a mist reduces air hunger in healthy volunteers in whom air hunger is induced experimentally in the lab. However, how much reduction varies among ind...
Eligibility Criteria
Inclusion
- \- Healthy volunteers aged 18 and over
Exclusion
- On any medication, including herbal medication (other than mild analgesics, vitamins and mineral supplements or, for females, oral contraceptives), whether prescribed or over-the-counter, in the two weeks prior to test sessions involving administration of furosemide or saline.
- Female participants who are pregnant, lactating or planning pregnancy over the course of trial
- A medical history of heart, kidney or liver disease/electrolyte disturbances/ immunosuppression/frequent fainting episodes/COPD/nasal polyps/Addison's/acute porphyria/significant prostatic symptoms/acute gout attack/life expectancy \<6months or history of allergic reaction to furosemide and/or any of the other ingredients of furosemide or amiloride, sulfonamides or sulphonamide derivatives, such as sulfadiazine or co-trimoxazole
- Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial.
- Have participated in another research trial involving an investigational product in the past 4 weeks.
Key Trial Info
Start Date :
October 14 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04130815
Start Date
October 14 2019
End Date
September 1 2020
Last Update
October 18 2019
Active Locations (1)
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1
Oxford Brookes University
Oxford, Oxfordshire, United Kingdom, OX3 0BP