Status:
COMPLETED
HIV Exposure in Utero and Metabolic Disease Risk in HIV-Negative Young Adults
Lead Sponsor:
Massachusetts General Hospital
Conditions:
HIV-exposed Uninfected
Eligibility:
All Genders
18+ years
Brief Summary
Globally, over 1 million babies are born to mothers with HIV each year. With the advent of prenatal antiretroviral therapy, up to 98% of these individuals may be HIV-exposed uninfected (HEU). A growin...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- HIV-Exposed Uninfected (HEU) Mother-Young Adult Dyads
- Male or female young adult, 18-35 years old
- Documentation of HIV infection in mother with date of diagnosis preceding young adult birth date
- Negative HIV test in young adult
- Control Mother-Young Adult Dyads
- Matching to HEU dyad
- Negative HIV test in mother and young adult
- EXCLUSION CRITERIA:
- All Young Adults
- Pregnancy within 6 months or active nursing
- Change in blood glucose or blood pressure medication within 3 months
- Change in estrogen or testosterone therapy within 3 months
- Chronic glucocorticoids (except steroid inhalers or creams) within 3 months
- Antiretroviral therapy use within 6 months (i.e., prophylaxis)
- Significant chronic illness judged by the investigator to represent a contraindication to participation
Exclusion
Key Trial Info
Start Date :
October 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 26 2024
Estimated Enrollment :
174 Patients enrolled
Trial Details
Trial ID
NCT04132830
Start Date
October 1 2019
End Date
July 26 2024
Last Update
September 23 2024
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114