Status:
RECRUITING
Ultrasound Imaging and Spectroscopy as Early Indicators of Locally-Advanced Breast Cancer Response
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Breast Cancer
Eligibility:
All Genders
18+ years
Brief Summary
This work explores the possibility of using ultrasound imaging and spectroscopy as a way of monitoring cell death, hence, tumour response to treatment. The hypothesis here is that it can be used as a ...
Detailed Description
The primary objective in this study is to identify optimal ultrasound spectroscopy parameters that can be used as an early predictor of pathological complete or partial response in women with locally ...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed locally advanced breast carcinoma which has not been treated with any first-line therapy and will be treated with neoadjuvant chemotherapy or neoadjuvant combined chemo-radiotherapy
- Measurable disease by ultrasound, or MRI performed within 28 days prior to treatment
- Eastern Co-operative Oncology Group (ECOG) Performance Status of 0 or 1
- Life expectancy of at least 6 months
- Patients should have the ability to understand and the willingness to sign a written informed consent document. Signed informed consent must be obtained prior to any study specific procedures
Exclusion
- History of allergic reactions attributed to compounds of similar chemical or biologic composition
- Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, and cardiac arrhythmia
- Psychiatric illness/social situations that would limit compliance with study requirements
- Any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2029
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04134780
Start Date
August 1 2014
End Date
October 1 2029
Last Update
December 14 2023
Active Locations (3)
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1
MD Anderson
Houston, Texas, United States, 77030
2
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
3
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9