Status:
RECRUITING
Imaging Biomarkers in Preclinical and Symptomatic AD
Lead Sponsor:
Tammie L. S. Benzinger, MD, PhD
Conditions:
Alzheimer Disease
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this research study is to evaluate adult children of parents with and without Alzheimer's disease which represent an ideal population for investigating the biological changes that prece...
Detailed Description
This study will use a radioactive tracer called \[11C\]-Pittsburgh Compound B (11C\]PIB), which is a tracer that binds to beta amyloid protein in the brain. This compound is considered investigational...
Eligibility Criteria
Inclusion
- Male or female, any race;
- Age ≥ 18 years;
- Active participants currently enrolled in the Knight Alzheimer's Disease Research Center (ADRC) at Washington University.
Exclusion
- Hypersensitivity to \[11C\] PIB or any of its excipients;
- Contraindications to PET, CT or MRI (e.g. electronic medical devices, inability to lie still for extended periods) that make it unsafe for the individual to participate;
- Severe claustrophobia;
- Women who are pregnant or breast-feeding will be excluded from PIB PET participation;
- Has any condition that, in the opinion of the Sponsor-Investigator or designee could increase risk to the subject, limit the subject's ability to tolerate the research procedures, or interfere with collection of the data;
- Currently participating in any clinical trial which involves an active study medication or placebo within the past 30 days before scanning and up to 2-weeks past the imaging visit.
- Current or recent (within 12 months prior to screening) participation in research studies involving radioactive agents such that the total research-related radiation dose to the participant in any given year would exceed the limits set forth in the U.S. Code of Federal Regulations (CFR) Title 21 Section 361.1. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?FR=361.1
Key Trial Info
Start Date :
June 8 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2029
Estimated Enrollment :
375 Patients enrolled
Trial Details
Trial ID
NCT04134923
Start Date
June 8 2021
End Date
October 1 2029
Last Update
August 7 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Washington University School of Medicine
St Louis, Missouri, United States, 63110