Status:
UNKNOWN
The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Aneurysmal Subarachnoid Hemorrhage
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
PHASE2
Brief Summary
Aneurysmal subarachnoid hemorrhage (aSAH) tended to lead to a sudden increase in intracerebral pressure (ICP), which can cause decreased cerebral perfusion and transient global cerebral ischemia. Earl...
Eligibility Criteria
Inclusion
- Patients with acute subarachnoid hemorrhage
- Patients who underwent frontal-temporal craniotomy pterional approach aneurysm clipping surgery under general anesthesia.
- Patients operated by the same surgeon (Dr. Chen Xiaolin).
Exclusion
- Patients who do not agree to the surgery.
- Patients who have congestive heart failure and kidney insufficiency.
- Patients who have pre-operative electrolyte imbalance.
- Patients who did not take the frontotemporal pterygoid approach.
- Patients with contraindications to mannitol due to low blood pressure.
- Patients who have had more than 3 days from bleeding to surgery.
- Patients with intracranial hematoma.
- Patients with Hunt-Hess grades 4-5.
- Patients who received intravenous mannitol within 6 hours before surgery.
- Patients who underwent ventricle puncture and drainage surgery before surgery.
Key Trial Info
Start Date :
April 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 14 2024
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT04135456
Start Date
April 20 2019
End Date
January 14 2024
Last Update
November 30 2023
Active Locations (1)
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1
Capital Medical University Affiliated Beijing Tiantan Hospital
Beijing, Beijing Municipality, China