Status:
UNKNOWN
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Lead Sponsor:
University of Nottingham
Conditions:
COPD
Cognitive Impairment
Eligibility:
All Genders
60-75 years
Brief Summary
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD). The changes...
Detailed Description
The aim is to recruit 20 participants with COPD, who will be compared to 10 age and gender matched controls who also have a smoking history. The investigators aim for this number to complete the compo...
Eligibility Criteria
Inclusion
- Patients aged 65-75 years old,
- \>10 pack years smoking,
- FEV1/FVC \<0.7 and FEV1\<60% predicted (for COPD participants only)
- Sedentary lifestyle (\<10,000 steps per day)
- Able to give informed consent
- Able to read, understand and communicate coherently in English
Exclusion
- Doctor diagnosis of ischaemic heart disease or heart failure
- Doctor diagnosis of dementia or Alzheimers disease
- History of previous cerebrovascular disease (stroke or TIA) or malignancy
- Pregnancy or childbearing in the last 6 months
- Maintenance oral corticosteroids in the past 6 months
- Requirement for oral corticosteroids or antibiotics in the past 6 weeks
- Active arthritis or other muscular condition limiting exercise
- Surgical intervention in the last 12 weeks
- Long term oxygen therapy requirement
- Other formal current respiratory diagnosis
- Thyroid disease
- Diabetes Mellitus
- Neurological or cognitive impairment
- Significant physical disability
- Any other conditions in addition to the above that the investigators consider may affect study measurements or safety
- Inability to understand verbal and/or written explanation of the study requirements
Key Trial Info
Start Date :
January 3 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04138563
Start Date
January 3 2019
End Date
September 30 2020
Last Update
October 30 2019
Active Locations (1)
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1
NIHR Nottingham BRC Respiratory Theme, University of Nottingham and NUH Trust
Nottingham, Nottinghamshire, United Kingdom, NG5 1PB