Status:
COMPLETED
Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB)
Lead Sponsor:
Aristotle University Of Thessaloniki
Conditions:
Type 1 Diabetes Mellitus
Eligibility:
All Genders
2-18 years
Brief Summary
Type 1 Diabetes Mellitus (T1DM) is a well-studied autoimmune disease resulting in insulin deficiency due to selective β-cell destruction. Epigenetics is a novel field of biology studying the inherited...
Detailed Description
Type 1 Diabetes Mellitus (T1DM) is a well-studied autoimmune disease resulting in insulin deficiency due to selective β-cell loss. Environmental and genetics factors seem to have a complex interplay i...
Eligibility Criteria
Inclusion
- Inclusion Criteria for both groups are:
- no history of T1DM or other autoimmune disease of their first degree relatives
- Greek origin (at least for 3 generations back to be Greek)
- sign written consent form
- Inclusion Criteria for patients are:
- males and females 2-18 years of age, with the diagnosis of T1DM
- T1DM diagnosis according to the criteria of International Society for Pediatric and Adolescent Diabetes (ISPAD) and ADA (American Diabetes Association)
- Inclusion Criteria for Controls are:
- healthy males and females 2-18 years of age, with no consaguinity with the patients
Exclusion
Key Trial Info
Start Date :
May 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04139369
Start Date
May 1 2012
End Date
August 1 2018
Last Update
October 25 2019
Active Locations (1)
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1
Unit of Pediatric Endocrinology, Diabetes and Metabolism-4th Department of Pediatrics, Medical School of Aristotle University of Thessaloniki
Thessaloniki, Greece, 56403