Completed

Phase Not Applicable
Age: 18Years - 35Years
All Genders
Healthy Volunteers
ID04214184

Biomarkers and Altered Metabolic Pathways During Sleep Loss

Led by University of Utah · Updated on 2026-04-30

38

Participants Needed

1

Research Sites

68 weeks

Total Duration

On this page

Sponsors

U

University of Utah

Lead Sponsor

U

University of Colorado, Boulder

Collaborating Sponsor

AI-Summary

What this Trial Is About

This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per night changes their plasma metabolome and insulin sensitivity. The primary outcome will examine changes in branched-chain amino acids and the secondary outcome will examine changes in insulin sensitivity. The investigators will also determine if changes in plasma metabolites can be used as a biomarker to discriminate between adequate versus insufficient sleep.

CONDITIONS

Official Title

Biomarkers of Increased Free Living Sleep Time

Who Can Participate

Age: 18Years - 35Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  1. 18-35 years old; men and women

    a. Equal numbers of women and men will be included.

  2. Body Mass Index (BMI) of > 18.5 and <24.9.

  3. Inactive to habitual moderate physical activity level (<5 days of exercise per week).

  4. Sleep/wake history: habitual sleep duration less than 6 hours per night.

  5. Altitude history: Potential participants must have lived at Denver altitude or higher for at least 3 months.

Not Eligible

You will not qualify if you...

  1. Any clinically significant unstable medical or surgical condition within the last year (treated or untreated).
  2. Any clinically significant psychiatric condition, as defined by DSM-IV-TR. I
  3. Any clinically significant sleep disorder.
  4. Use of prescription medications/supplements within one month or need of these medications at any time during the study.
  5. Symptoms of active illness (e.g., fever).
  6. Uncorrected visual impairment
  7. History of shift work in prior year or travel more than one time zone in three weeks prior to study.
  8. Participants must be entirely drug-free of illicit drugs, medications, nicotine and herbal products for one month prior to study.
  9. Blood donation in the 30 days prior to inpatient study.
  10. Ovulating women will be selected on the basis of a history of regular menstrual cycle ranging in length from 25-32 days with a maximum of three days variation month-to-month. They will have no history of prior gynecological pathology, be at least 1 year post-partum, not breast-feeding and not pregnant (HCG pregnancy test at screening and upon admission to the inpatient protocol).

Trial Site Locations

Total: 1 location

1

Sleep Wake Center--University of Utah

Salt Lake City, Utah, United States, 84108

Status Unknown

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

1

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Published Research Related To This Trial

From yawn to dawn: the effects of a sleep extension intervention on objective and subjective dimensions of sleep health in adults with habitual short sleep duration.

Audrey P Stegman, Michelle Kubicki, Zachary Mallender...

https://pubmed.ncbi.nlm.nih.gov/41768370