Status:

RECRUITING

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Lead Sponsor:

Daniel Claassen

Conditions:

Autonomic Failure

Pure Autonomic Failure

Eligibility:

All Genders

18+ years

Phase:

PHASE1

Brief Summary

Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of alpha-sy...

Eligibility Criteria

Inclusion Criteria:

  1. Patients with a diagnosis if pure autonomic failure
  2. Patients with autonomic failure and possible PD, MSA, or DLB
  3. Healthy adults aged 18 and above
  4. Clinical exam confirming clinical designation

Exclusion Criteria:

  • Subjects who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.), because such devices may be displaced or malfunction.
  • Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced.
  • Subjects who have cerebral aneurysm clips.
  • Subjects who may have shrapnel imbedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).
  • Subjects who are pregnant, because the effects of high field MRI on fetuses are not yet known.
  • Minors (younger than 18 years)

Also excluded are subjects incapable of giving informed written consent:

  • Subjects who cannot adhere to the experimental protocols for any reason, or have an inability to communicate with the researcher.
  • Subjects who have limited mental ability to give informed consent, mentally retarded, altered mental status, mental disability, confusion, or psychiatric disorders.
  • Prisoners

Key Trial Info

Start Date :

February 4 2020

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

February 1 2027

Estimated Enrollment :

40 Patients enrolled

Trial Details

Trial ID

NCT04246437

Start Date

February 4 2020

End Date

February 1 2027

Last Update

March 16 2026

Active Locations (1)

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Page 1 of 1 (1 locations)

1

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37212

[18F]F-DOPA Imaging in Patients With Autonomic Failure | DecenTrialz