Status:
RECRUITING
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Lead Sponsor:
Daniel Claassen
Conditions:
Autonomic Failure
Pure Autonomic Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of alpha-sy...
Eligibility Criteria
Inclusion Criteria:
- Patients with a diagnosis if pure autonomic failure
- Patients with autonomic failure and possible PD, MSA, or DLB
- Healthy adults aged 18 and above
- Clinical exam confirming clinical designation
Exclusion Criteria:
- Subjects who have any type of bioimplant activated by mechanical, electronic, or magnetic means (e.g., cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps, etc.), because such devices may be displaced or malfunction.
- Subjects who have any type of ferromagnetic bioimplant that could potentially be displaced.
- Subjects who have cerebral aneurysm clips.
- Subjects who may have shrapnel imbedded in their bodies (such as from war wounds), metal workers and machinists (potential for metallic fragments in or near the eyes).
- Subjects who are pregnant, because the effects of high field MRI on fetuses are not yet known.
- Minors (younger than 18 years)
Also excluded are subjects incapable of giving informed written consent:
- Subjects who cannot adhere to the experimental protocols for any reason, or have an inability to communicate with the researcher.
- Subjects who have limited mental ability to give informed consent, mentally retarded, altered mental status, mental disability, confusion, or psychiatric disorders.
- Prisoners
Key Trial Info
Start Date :
February 4 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04246437
Start Date
February 4 2020
End Date
February 1 2027
Last Update
March 16 2026
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212