Status:
COMPLETED
CSF/Serum Biomarkers in Predicting PND/Persistent Pain After Cesarean
Lead Sponsor:
Duke University
Conditions:
Perinatal Depression
Chronic Pain
Eligibility:
FEMALE
18-40 years
Brief Summary
The aim is to investigate if inflammatory biomarkers in the blood and cerebrospinal fluid (CSF) are associated with the development of perinatal depression and/or persistent pain after cesarean delive...
Detailed Description
Persistent pain and perinatal depression (PND) contribute significantly to maternal morbidity and mortality after cesarean delivery. Neuroinflammation has been associated with both persistent pain and...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists (ASA) class 2 and 3
- English speaking
- 18 years or older
- Singleton pregnancy
- Gestational age \> 37 weeks
- Scheduled cesarean delivery under spinal or combined spinal epidural anesthesia
Exclusion
- Intravenous drug or chronic opioid use
- Anti-depressant or anxiolytic drug use
- Allergy to standard of care drugs
- Cesarean delivery under general anesthesia or epidural anesthesia
- Pre-eclampsia needing magnesium sulfate
- Chronic PO/IV analgesic or glucocorticoids
- History of chronic pain syndromes
Key Trial Info
Start Date :
February 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 28 2022
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT04271072
Start Date
February 1 2020
End Date
February 28 2022
Last Update
December 20 2023
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710