Status:
COMPLETED
RAI & HRS: Relationship Between Relative Adrenal Insufficiency and Failure of Treatment in Hepatorenal Syndrome
Lead Sponsor:
University Hospital Plymouth NHS Trust
Conditions:
Liver Cirrhosis
Acute Kidney Injury
Eligibility:
All Genders
18-80 years
Brief Summary
Hepatorenal syndrome is a life-threatening medical condition and a serious complication of advanced liver scarring (cirrhosis). It consists of a deterioration of the function of the kidneys caused by ...
Detailed Description
This is a prospective, observational, descriptive, clinical study. This is a single centre study. All patients admitted to the South West Liver Unit with decompensated cirrhosis will be screened acco...
Eligibility Criteria
Inclusion
- Subjects capable of giving informed consent, or in case of lack of capacity, their legal representative consent on their behalf.
- Older than 18 years old and younger than 80 years old.
- Diagnosis of cirrhosis according to liver biopsy, or non-invasive markers (Fibroscan) or a combination of clinical and imaging criteria.
- Diagnosis of AKI stage 2-3 or stage 1 with serum Creatinine \> 133 µmol/L, according to the last international consensus (International Club of Ascites, 2015)
Exclusion
- Advanced hepatocellular carcinoma, Barcelona-Clinic liver cancer (BCLC) stage C or D
- Infection by human immunodeficiency virus (HIV)
- Previous transplant or any other type of immunodeficiency
- Pregnancy
- Long-term treatment with steroids or other immunosuppressive agents or interferon
- Severe chronic heart failure, New York Heart Association (NYHA), class III or IV
- Advanced COPD, global initiative for chronic obstructive lung disease (GOLD) III or IV
- Renal failure on haemodialysis
- Any medical condition that gives a survival shorter than 3 months
Key Trial Info
Start Date :
March 5 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 5 2020
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04273750
Start Date
March 5 2018
End Date
February 5 2020
Last Update
February 18 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospitals Plymouth NHS Trust
Plymouth, Devon, United Kingdom, PL6 8DH