Status:
UNKNOWN
Effects of Fat Emulsions on PNALD and Oxidative Stress in Premature Infants
Lead Sponsor:
Shanghai Jiao Tong University School of Medicine
Conditions:
Preterm Infant
Eligibility:
All Genders
1-28 years
Phase:
PHASE4
Brief Summary
Abnormal liver function or cholestasis is the result of multiple factors, include low birth weight, smaller than gestational age, preterm birth, infection, lipid emulsion (LE) in parenteral nutrition ...
Detailed Description
For preterm infants, especially for very or extremely low birth weight infants, it's impossible to achieve total enteral feeding in short time. So, PN has played an important role to sustain normal li...
Eligibility Criteria
Inclusion
- Premature infants (gestational age \< 32 weeks) with birth weight \< 1500g were admitted to NICU of Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China within 24 hours after birth
- No contraindications to parenteral nutrition
- Expected PN support for 14 days or more
- Parents or guardians agree
Exclusion
- Parenteral nutrition support was provided prior to enrollment
- EN calorie for 10% or more
- Congenital intestinal structural/functional abnormalities
- Liver function damage caused by viral hepatitis, genetic metabolism and abnormal biliary tract
- Congenital or acquired immunodeficiency
- Complex congenital heart disease
Key Trial Info
Start Date :
February 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2021
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT04277923
Start Date
February 1 2020
End Date
August 1 2021
Last Update
February 20 2020
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